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Exenatide Acetate
Cat #
KTA-23
Introduction
Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II. This product is offered under Bolar Exemption.
Sequence
H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt
MW
4186.63
Reference
J. Eng et al., J. Biol. Chem., 267, 7402 (1992)
H. C. Fehmann et al., Peptides, 15, 453 (1994)
N. Giannoukakis, Curr. Opin. Invest. Drugs, 4, 459 (2003)
T. -A. Perry and N.H.Greig, Trends Pharmacol. Sci., 24, 377 (2003)
L. Brunetti et al., Peptides, 29, 1377 (2008)
G. Bertilsson et al., J. Neurosci. Res., 86, 326 (2008)
M. Marzioni et al., Gut, 58, 990 (2009)
Fields of application
Type 2 diabetes
Synonyms
Exendin-4
Structure
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